The main themes of Obregón's paintings are portraits of family and friends as well as several self-portraits, from a very Cézannian one of the painter sitting while holding a brush (1943), to Daedalus (Dédalo, 1985), and Blas de Lezos (1977-1978); animals, an endless fauna that spans the range from condors and bulls to barracudas, mojarras, and shrimp, goats and iguanas; carnivorous and nocturnal flowers; scenes of violence; and, above all, landscapes, with clear allusions to the sea, beaches, storms, eclipses, and especially winds. These themes recur and therefore do not present themselves in chronological order. As the artist rightly said, more than specific motifs, his paintings refer to "drama, catastrophe, a record of life, reportage, and a little bit of everything."